Loc N K, Oláh I, Takács L, Kittner Z
Acta Morphol Acad Sci Hung. 1981;29(4):319-33.
A single large dose (200 mg/kg) of cyclophosphamide (Cy) caused thymic involution. Thymic cortex was almost depleted of lymphocytes while medullary thymocytes were not affected. This resulted in thymic inversion on day 4. During the period of involution the cortex was invaded by positive acid phosphatase granules containing macrophages. Later the cytoplasms of these macrophages were loaded with lipid droplets and residual materials. Extensive vacuolization of the cytoplasms of epithelial and special cells were revealed. Regeneration began on day 4. Repopulating cells appeared primarily in subcapsular region. Regeneration was complete by day 11 as examined by morphological technics. While FCS dependent rosette formation capacity remained below the control level even on day 16.
单次大剂量（200毫克/千克）的环磷酰胺（Cy）导致胸腺萎缩。胸腺皮质的淋巴细胞几乎耗尽，而髓质胸腺细胞未受影响。这导致在第4天出现胸腺反转。在萎缩期间，皮质被含有酸性磷酸酶颗粒的巨噬细胞侵入。后来这些巨噬细胞的细胞质中充满了脂滴和残余物质。上皮细胞和特殊细胞的细胞质出现广泛空泡化。再生在第4天开始。再填充细胞主要出现在被膜下区域。通过形态学技术检查，到第11天再生完成。而即使在第16天，依赖胎牛血清的玫瑰花结形成能力仍低于对照水平。
