Loc N K, Oláh I, Kittner Z, Takács L, Törö I
Acta Morphol Acad Sci Hung. 1981;29(4):335-51.
A single large dose (200 mg) of cyclophosphamide (Cy) given to adult rats caused a drastic depletion of lymphocytes occurring earlier in the B dependent compartment than in the T dependent one of the lymph node cortex. The drug had a somewhat facilitating effect on the early differentiation of plasma cells (between 12 and 24 h) which later were also depleted. By Cy administration two types of macrophage were distinguished morphologically and topographically in the lymph nodes. Cy effect the endothelial cells lining the blood vessels and lymph sinuses. From day 4 to 7 Cy caused a constant flooding of red blood cells into the lymph node sinuses like in the normal rat haemolymph gland. Regeneration of the mesenteric lymph nodes occurred by a repopulation of lymphoid cells and a proliferation of other cell types. Repopulation of the B dependent compartment lagged behind that of the T dependent compartment. Regeneration of endothelial cells seemed to be one of the factors facilitating the repopulation of lymphoid cells. The distribution of T and B dependent cells in different compartments of the rat lymph node and activation of mononuclear phagocytes in Cy treated rat lymph node are discussed.
给成年大鼠单次大剂量（200毫克）环磷酰胺（Cy），可导致淋巴细胞急剧减少，这种减少在淋巴结皮质中依赖B细胞的区域比依赖T细胞的区域出现得更早。该药物对浆细胞的早期分化（12至24小时之间）有一定的促进作用，不过后期浆细胞也会减少。通过给予环磷酰胺，在淋巴结中从形态学和拓扑学上区分出了两种巨噬细胞。环磷酰胺影响血管和淋巴窦内衬的内皮细胞。从第4天到第7天，环磷酰胺导致红细胞持续涌入淋巴结窦，就像正常大鼠的血淋巴腺一样。肠系膜淋巴结的再生是通过淋巴细胞的重新填充和其他细胞类型的增殖实现的。依赖B细胞区域的重新填充落后于依赖T细胞的区域。内皮细胞的再生似乎是促进淋巴细胞重新填充的因素之一。本文讨论了大鼠淋巴结不同区域中依赖T细胞和B细胞的细胞分布以及环磷酰胺处理的大鼠淋巴结中单核吞噬细胞的激活情况。
