Capasso F
Agents Actions. 1981 Dec;11(6-7):741-5. doi: 10.1007/BF01978799.
Tiopronin (50 mg/kg) and D-penicillamine (50 mg/kg) do not exhibit anti-inflammatory effects in classic animal models (carragenin oedema, granuloma cotton pellets) but suppress pertussis vaccine oedema, an immunological model, when given with a long-lasting dosing regime. Tiopronin and D-penicillamine also fail to inhibit PG release by phagocytosing leucocytes when the concentrations used were in the same range as human blood levels (5-15 micrograms/ml). Indomethacin (1, 3 and 5 mg/kg) instead significantly inhibits both the in vivo and in vitro models considered. This may imply a different mode of action of both tiopronin and D-penicillamine from indomethacin. Tiopronin also possesses similar effects to D-penicillamine suggesting that their overall anti-rheumatic action may have common elements.
硫普罗宁（50毫克/千克）和青霉胺（50毫克/千克）在经典动物模型（角叉菜胶水肿、棉球肉芽肿）中未表现出抗炎作用，但在采用长期给药方案时，可抑制百日咳疫苗水肿（一种免疫模型）。当所用浓度与人体血液水平（5 - 15微克/毫升）相当时，硫普罗宁和青霉胺也无法抑制吞噬白细胞释放前列腺素。相反，吲哚美辛（1、3和5毫克/千克）能显著抑制所考虑的体内和体外模型。这可能意味着硫普罗宁和青霉胺与吲哚美辛的作用模式不同。硫普罗宁也具有与青霉胺相似的作用，表明它们总体的抗风湿作用可能有共同的要素。
