百日咳疫苗水肿：一种用于青霉胺类药物作用的实验模型。
Pertussis vaccine oedema: an experimental model for the action of penicillamine-like drugs.
作者信息
Arrigoni-Martelli E, Bramm E, Huskisson E C, Willoughby D A, Dieppe P A
出版信息
Agents Actions. 1976 Sep;6(5):613-7. doi: 10.1007/BF01971579.
PMID:970290
Abstract
A delayed hypersensitivity response was induced in the rat paw using pertussis vaccine. Oedema was measured after the challenging injection. D-penicillamine and levamisole enhanced the response, while indomethacin suppressed it. This model is useful to distinguish the effects of anti-inflammatory drugs from those like D-Penicillamine which have a specific activity in rheumatoid arthritis.
摘要
使用百日咳疫苗在大鼠爪部诱导迟发型超敏反应。在激发注射后测量水肿情况。D-青霉胺和左旋咪唑增强了该反应，而吲哚美辛则抑制了该反应。该模型有助于区分抗炎药物与像D-青霉胺这类在类风湿性关节炎中具有特定活性的药物的作用。
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