Alton G G, Corner L A
Aust Vet J. 1981 Dec;57(12):548-50. doi: 10.1111/j.1751-0813.1981.tb00431.x.
Ten Jersey heifers aged 14 to 23 months were vaccinated with 2.25 x 10(8) cells of living Brucella abortus strain 19 vaccine. They and 10 similar non-vaccinated heifers were subsequently mated and when about 6 months pregnant were challenged by the conjunctival application of a virulent culture of B. abortus. The serological responses to vaccination was much less than is usually seen following vaccination with the normal dose of strain 19, especially when the indirect haemolysis test was used. A persistent vaccinal reaction was observed in one heifer. Significant resistance to infection was demonstrated which was greater than that previously observed in calfhood vaccinates given the full dose but less than that shown by cows given the smaller dose in early pregnancy. The effectiveness of strain 19 vaccination appears to be related to the age of the animal at vaccination.
10头年龄在14至23个月的泽西小母牛用2.25×10⁸个活布鲁氏菌流产菌株19疫苗细胞进行接种。随后，它们与10头类似的未接种疫苗的小母牛进行交配，当怀孕约6个月时，通过结膜接种强毒布鲁氏菌流产菌株进行攻毒。与通常接种正常剂量菌株19后所见的情况相比，接种疫苗后的血清学反应要小得多，尤其是使用间接溶血试验时。在一头小母牛中观察到持续的疫苗反应。证明了对感染有显著的抵抗力，这种抵抗力大于之前在犊牛期接种全剂量疫苗的牛所观察到的抵抗力，但小于在怀孕早期接种较小剂量疫苗的母牛所表现出的抵抗力。菌株19疫苗接种的有效性似乎与接种时动物的年龄有关。
