库普弗细胞上的D-半乳糖受体是否会循环利用？
Does the D-galactose receptor on Kupffer cells recycle?
作者信息
Kolb H, Vogt D, Kolb-Bachofen V
出版信息
Biochem J. 1981 Nov 15;200(2):445-8. doi: 10.1042/bj2000445.
Abstract
Kupffer cells carry on the cell surface a lectin-like receptor with specificity for D-galactose/D-glucose residues. After tryptic digestion of receptors, new lectin activity appears on the plasma membrane within 15 min. Protein biosynthesis de novo is not involved. This indicates the transfer of new lectin molecules stored within the cell to the cell surface. Kupffer cells can enter a physiological state where receptor recycling does not take place.
摘要
库普弗细胞在细胞表面带有一种对D-半乳糖/D-葡萄糖残基具有特异性的凝集素样受体。在对受体进行胰蛋白酶消化后，15分钟内在质膜上出现新的凝集素活性。这一过程不涉及从头合成蛋白质。这表明细胞内储存的新凝集素分子转移到了细胞表面。库普弗细胞可以进入一种不发生受体循环利用的生理状态。
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