Cha C W
Department of Preventive Medicine, College of Medicine, Korea University, Seoul.
J Korean Med Sci. 1987 Dec;2(4):213-24. doi: 10.3346/jkms.1987.2.4.213.
When garlic (Allium sativum) was administered to rat per os simultaneously with cadmium, methylmercury and phenylmercury to detect the protective effect against the heavy metal poisoning, accumulation of heavy metals in liver, kidneys, bone and testes were decreased, and histopathological damages and the inhibition of serum alkaline phosphatase activities by heavy metals were reduced. Such effect of garlic was not shown in the 1.7% garlic treated group and most remarkable in the 6.7% garlic treated group. The protective effect of garlic was superior to those of 2,3 dimercapto-1-propanol (BAL) and D-penicillamine (PEN), and nearly similar to those of 2,3-dimercaptosuccinic acid (DMSA) and N-acetyl-DL-penicillamine (APEN), the current remedies, while garlic was not effective as a curative agent for heavy metal poisoning. The excretion of cadmium was enhanced, more through feces than urine by garlic but the effect to the urinary excretion of cadmium was not significant comparing with DMSA or APEN when cadmium was ip injected in the first 3 days during the 12 days of oral administration of DMSA, APEN or garlic.
为检测大蒜（Allium sativum）对重金属中毒的保护作用，将其与镉、甲基汞和苯基汞同时经口给予大鼠，结果显示，肝脏、肾脏、骨骼和睾丸中重金属的蓄积减少，重金属所致的组织病理学损伤及血清碱性磷酸酶活性的抑制作用减轻。大蒜的这种作用在1.7%大蒜处理组未表现出来，而在6.7%大蒜处理组最为显著。大蒜的保护作用优于2,3-二巯基-1-丙醇（BAL）和D-青霉胺（PEN），与目前的治疗药物2,3-二巯基丁二酸（DMSA）和N-乙酰-DL-青霉胺（APEN）相近，不过大蒜作为重金属中毒的治疗药物并无效果。大蒜可促进镉的排泄，经粪便排泄的镉多于尿液，但在口服DMSA、APEN或大蒜12天期间，在前3天腹腔注射镉时，与DMSA或APEN相比，大蒜对镉尿排泄的作用并不显著。
