β受体阻滞剂在长期治疗期间的降压活性比较。
Comparison of antihypertensive activity of beta-blocking drugs during chronic treatment.
作者信息
Davidson C, Thadani U, Singleton W, Taylor S H
出版信息
Br Med J. 1976 Jul 3;2(6026):7-9. doi: 10.1136/bmj.2.6026.7.
Abstract
The hypotensive activity of five beta-adrenoceptor antagonists with different ancillary pharmacological properties was compared in a randomised double-blind factorial trial in 25 untreated patients with stable, uncomplicated essential hypertension. In doses that produced similar reductions in exercise tachycardia all drugs had similar blood-pressure lowering activity, greater on systolic than diastolic pressure and greatest during exercise. With the exception of vasodilator activity the possession of any particular combinaton of ancillary pharmacological properties did not significantly influence the specific antihypertensive activity of these compounds.
摘要
在一项针对25名未经治疗的稳定、无并发症原发性高血压患者的随机双盲析因试验中，比较了五种具有不同辅助药理特性的β肾上腺素能受体拮抗剂的降压活性。在能使运动性心动过速产生相似降低幅度的剂量下，所有药物的降压活性相似，收缩压降低幅度大于舒张压，且运动期间降压作用最强。除血管舒张活性外，具有任何特定辅助药理特性组合对这些化合物的特定降压活性均无显著影响。
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