用热原预处理的大鼠中氯喹的致死性和组织水平增强。
Enhanced lethality and tissue levels of chloroquine in rats pretreated with pyrogen.
作者信息
Osifo N G, DiStefano V
出版信息
Res Commun Chem Pathol Pharmacol. 1978 Dec;22(3):513-21.
PMID:734231
Abstract
The lethality, and concentrations of chloroquine in plasma, brain liver and heart, in control and pyrogen-treated rats were investigated. Pyrogen treatment increased the lethality, the convulsive activity, plasma and myocardial concentrations of chloroquine significantly. The results suggest that the initiation of therapy with chloroquine in acute febrile conditions may require smaller than usual dosage.
摘要
研究了对照大鼠和致热原处理大鼠中氯喹的致死率以及其在血浆、脑、肝脏和心脏中的浓度。致热原处理显著增加了氯喹的致死率、惊厥活性、血浆和心肌浓度。结果表明，在急性发热情况下开始使用氯喹治疗时，可能需要比通常剂量更小的剂量。
相似文献
1
Enhanced lethality and tissue levels of chloroquine in rats pretreated with pyrogen.用热原预处理的大鼠中氯喹的致死性和组织水平增强。
Res Commun Chem Pathol Pharmacol. 1978 Dec;22(3):513-21.
2
Chloroquine pharmacokinetics in tissues of pyrogen treated rats and implications for chloroquine related pruritus.氯喹在致热原处理大鼠组织中的药代动力学及其与氯喹相关瘙痒的关系
Res Commun Chem Pathol Pharmacol. 1980 Dec;30(3):419-30.
3
The effect of pyrogen on the in vivo metabolism and initial kinetics of chloroquine in rats.热原对大鼠体内氯喹代谢及初始动力学的影响。
J Pharm Pharmacol. 1979 Nov;31(11):747-51. doi: 10.1111/j.2042-7158.1979.tb13650.x.
4
5
Plasma nicotinic acid level in chloroquine treated rats.氯喹治疗大鼠的血浆烟酸水平。
Afr J Med Med Sci. 2000 Mar;29(1):45-6.
6
7
8
Absorption, distribution and excretion of 14C-chloroquine after single oral administration in albino and pigmented rats: binding characteristics of chloroquine-related radioactivity to melanin in-vivo.白化病大鼠和有色大鼠单次口服给药后14C-氯喹的吸收、分布和排泄：氯喹相关放射性在体内与黑色素的结合特性
J Pharm Pharmacol. 2003 Dec;55(12):1647-54. doi: 10.1211/0022357022340.
9
Plasma and tissue levels of digoxin in the rat following pretreatment with verapamil.维拉帕米预处理后大鼠体内地高辛的血浆和组织水平。
Res Commun Chem Pathol Pharmacol. 1985 Mar;47(3):469-72.
10
Pathophysiological and pharmacological mechanisms of acute cocaine toxicity in conscious rats.清醒大鼠急性可卡因毒性的病理生理和药理机制
J Pharmacol Exp Ther. 1992 Sep;262(3):936-46.
Zotero 插件