用热原预处理的大鼠中氯喹的致死性和组织水平增强。
Enhanced lethality and tissue levels of chloroquine in rats pretreated with pyrogen.
作者信息
Osifo N G, DiStefano V
出版信息
Res Commun Chem Pathol Pharmacol. 1978 Dec;22(3):513-21.
PMID:734231
Abstract
The lethality, and concentrations of chloroquine in plasma, brain liver and heart, in control and pyrogen-treated rats were investigated. Pyrogen treatment increased the lethality, the convulsive activity, plasma and myocardial concentrations of chloroquine significantly. The results suggest that the initiation of therapy with chloroquine in acute febrile conditions may require smaller than usual dosage.
摘要
研究了对照大鼠和致热原处理大鼠中氯喹的致死率以及其在血浆、脑、肝脏和心脏中的浓度。致热原处理显著增加了氯喹的致死率、惊厥活性、血浆和心肌浓度。结果表明，在急性发热情况下开始使用氯喹治疗时，可能需要比通常剂量更小的剂量。
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