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近端选择性迷走神经切断术对食管的副作用。II. 食管动力及食管下括约肌影响的实验研究(作者译)

[Side effects of proximal selective vagotomy on the esophagus. II. Experimental study of effects of the esophageal motility and the lower esophageal sphincter (author's transl)].

作者信息

Buchmann P, Rehli V, Ruckert R, Blum A, Largiadèr F

出版信息

Res Exp Med (Berl). 1978 Dec 27;174(1):47-55. doi: 10.1007/BF01851938.

Abstract

The influence of the proximal selective vagotomy (PSV) with mobilisation of the esophagus of 6 cm or up to the upper thorax apertura on esophageal motility in a first group and mobilisation of 2 or 7 cm on the lower esophageal sphincter tone in a second group was investigated in canine experiments. The loss of coordinated peristalsis in the denuded segment causes a deterioration of esophageal passage. The degree of disturbance of swallowing depends on the length of the mobilisation. Reduction of lower esophageal pressure was observed. These reduction was not influenced by the extent of this motilisation. Acid reflux was not seen. Due to anatomical differences between these two species, these results cannot be readely transferred to human. Enlarged mobilisation of the esophagus for completion of PSV cannot be recommanded without reservation. Clinical studies are needed.

摘要

在犬类实验中,研究了第一组近端选择性迷走神经切断术(PSV)联合6厘米食管游离或直至上胸部开口对食管动力的影响,以及第二组2厘米或7厘米食管游离对食管下括约肌张力的影响。剥脱段协调性蠕动的丧失导致食管通过功能恶化。吞咽障碍的程度取决于游离的长度。观察到食管下压力降低。这种降低不受这种游离程度的影响。未观察到酸反流。由于这两个物种之间的解剖学差异,这些结果不能轻易推广到人类。在没有保留意见的情况下,不能推荐为完成PSV而扩大食管游离范围。需要进行临床研究。

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