Maeda Y, Hashiguchi T
Anim Blood Groups Biochem Genet. 1981;12(4):277-85. doi: 10.1111/j.1365-2052.1981.tb01560.x.
Trends in heterozygosity in the process of producing inbred strains of Japanese quail were examined through the characterization of protein polymorphisms based on gene freqencies of 7 polymorphic loci. The average heterozygosity (Ho) at generation 1 was 0.472 and it decreased with increasing inbreeding coefficient (F) to 0.214 at generation 5 when F was 0.594. In all generations, the observed heterozygosities of the surviving families tended to be higher than those of the families that did not survive. The frequency of heterozygotes of the Es-4 locus in surviving families was higher than that of the extinct families in each generation and the difference became conspicuous in generation 4. These results suggest that a heterozygote advantage of Es-4 locus is revealed by inbreeding.
通过基于7个多态位点的基因频率对蛋白质多态性进行表征，研究了日本鹌鹑近交系培育过程中的杂合性趋势。第1代的平均杂合度（Ho）为0.472，随着近交系数（F）的增加，在第5代F为0.594时降至0.214。在所有世代中，存活家族的观察杂合度往往高于未存活家族。Es-4位点杂合子在存活家族中的频率在各代均高于灭绝家族，且在第4代差异变得明显。这些结果表明，Es-4位点的杂合优势通过近交得以显现。
