Delatour P, Parish R C, Gyurik R J
Ann Rech Vet. 1981;12(2):159-67.
By using an experimental model compound (Albendazole, an anthelmintic) the authors compared two methodologies for the toxicological evaluation of bovine hepatic residues. Toxicity was not demonstrated for bovine hepatic residues in a relay embryotoxicity study in the rat. On the other hand, both albendazole and its sulfoxide metabolite produce embryotoxic effects in this rat model. These different results are discussed and explained by considerations related to the no effect levels and the chemical nature of the different types of residues.
通过使用一种实验模型化合物（阿苯达唑，一种驱虫药），作者比较了两种用于牛肝残留毒理学评估的方法。在大鼠的接力胚胎毒性研究中，未证明牛肝残留具有毒性。另一方面，在该大鼠模型中，阿苯达唑及其亚砜代谢物均产生胚胎毒性作用。通过与不同类型残留的无效应水平和化学性质相关的考虑因素，对这些不同结果进行了讨论和解释。
