Induction of 5-aminolaevulinate synthase in chick embryo liver by propylisopropylacetamide does not involve destruction of cytochrome P-450.
作者信息
Sinclair P R, Healey J F, Sinclair J F, Bonkowsky H L
出版信息
Biochem J. 1981 Dec 15;200(3):709-10. doi: 10.1042/bj2000709.
Abstract
摘要
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Induction of 5-aminolaevulinate synthase in chick embryo liver by propylisopropylacetamide does not involve destruction of cytochrome P-450.丙基异丙基乙酰胺对鸡胚肝脏中5-氨基乙酰丙酸合酶的诱导作用不涉及细胞色素P-450的破坏。
Biochem J. 1981 Dec 15;200(3):709-10. doi: 10.1042/bj2000709.
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Evidence that in chick embryos destruction of hepatic microsomal cytochrome P-450 haem is a general mechanism of induction of delta-aminolaevulinate synthase by porphyria-causing drugs.有证据表明，在鸡胚中，肝微粒体细胞色素P - 450血红素的破坏是卟啉症致病药物诱导δ-氨基乙酰丙酸合酶的一般机制。
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Induction of cytochrome P-450 RNA by porphyrogenic agents: on the nature of the coordinate induction with delta-aminolevulinate synthase in tissues of the chicken embryo.致卟啉剂对细胞色素P-450 RNA的诱导作用：关于鸡胚组织中与δ-氨基乙酰丙酸合酶协同诱导的本质
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Tryptophan pyrrolase in haem regulation. The mechanisms of enhancement of rat liver 5-aminolaevulinate synthase activity by starvation and of the glucose effect on induction of the enzyme by 2-allyl-2-isopropylacetamide.血红素调节中的色氨酸吡咯酶。饥饿增强大鼠肝脏5-氨基酮戊酸合酶活性的机制以及葡萄糖对2-烯丙基-2-异丙基乙酰胺诱导该酶的影响。
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The influence of allyl isopropyl acetamide on d-aminolevulinic acid synthetase and cytochrome P-450.烯丙基异丙基乙酰胺对d-氨基乙酰丙酸合成酶和细胞色素P-450的影响。
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Effect of allylisopropylacetamide on glutathione metabolism in the rat liver. The possible role of glutathione in the induction of 5-aminolaevulinate synthase.烯丙基异丙基乙酰胺对大鼠肝脏谷胱甘肽代谢的影响。谷胱甘肽在诱导5-氨基乙酰丙酸合酶中的可能作用。
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本文引用的文献
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THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.肝微粒体的一氧化碳结合色素。I. 其血红蛋白性质的证据。
J Biol Chem. 1964 Jul;239:2370-8.
2
Evidence that in chick embryos destruction of hepatic microsomal cytochrome P-450 haem is a general mechanism of induction of delta-aminolaevulinate synthase by porphyria-causing drugs.有证据表明，在鸡胚中，肝微粒体细胞色素P - 450血红素的破坏是卟啉症致病药物诱导δ-氨基乙酰丙酸合酶的一般机制。
Biochem J. 1980 Sep 15;190(3):519-26. doi: 10.1042/bj1900519.
3
Role of haem in the induction of cytochrome P-450 by phenobarbitone. Studies in chick embryos in ovo and in cultured chick embryo hepatocytes.血红素在苯巴比妥诱导细胞色素P-450中的作用。对鸡胚在体及培养的鸡胚肝细胞的研究。
Biochem J. 1981 Aug 15;198(2):321-9. doi: 10.1042/bj1980321.
4
Drug-induced porphyrin biosynthesis--XII. Levels of cytochrome P-450 in chick embryo liver following administration of allylisopropylacetamide and propylisopropylacetamide.药物诱导的卟啉生物合成——十二。给予烯丙基异丙基乙酰胺和丙基异丙基乙酰胺后鸡胚肝脏中细胞色素P-450的水平
Can J Physiol Pharmacol. 1974 Aug;52(4):891-5. doi: 10.1139/y74-114.
5
6
Hormonal requirements for the induction of cytochrome P-450 in hepatocytes cultured in a serum-free medium.
Biochem Biophys Res Commun. 1979 Feb 14;86(3):710-7. doi: 10.1016/0006-291x(79)91771-6.
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