氧自由基与盆腔粘连形成：I. 在子宫内膜异位症模型中阻断氧自由基毒性以预防粘连形成
Oxygen free radicals and pelvic adhesion formation: I. Blocking oxygen free radical toxicity to prevent adhesion formation in an endometriosis model.
作者信息
Portz D M, Elkins T E, White R, Warren J, Adadevoh S, Randolph J
机构信息
University of Michigan Medical Center, Department of Obstetrics and Gynecology, Ann Arbor.
出版信息
Int J Fertil. 1991 Jan-Feb;36(1):39-42.
PMID:1672675
Abstract
Intraperitoneal superoxide dismutase (SOD) and catalase were used to block the toxic effects of superoxide anion (O2) and hydrogen peroxide (H2O2), associated with the production of endometriosis and inflammation in a rabbit model. In a two-part animal study, the combined instillation of SOD and catalase significantly reduced the formation of intraperitoneal adhesions at endometriosis sites.
摘要
在兔模型中，腹腔内注射超氧化物歧化酶（SOD）和过氧化氢酶，以阻断超氧阴离子（O2）和过氧化氢（H2O2）的毒性作用，这些毒性作用与子宫内膜异位症和炎症的产生相关。在一项分为两部分的动物研究中，联合注入SOD和过氧化氢酶可显著减少子宫内膜异位症部位腹腔粘连的形成。
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