Fröber R, Halbhuber K J, Unger J, Linss W, Stein G, Speerschneider H, Stoll W, Geyer G
Gegenbaurs Morphol Jahrb. 1981;127(5):654-8.
The study is concerned with factors that may reduce the life time of erythrocytes of patients under intermittent haemodialysis. The red cell population of these patients consisted of micro-, normo-, macro- and megalocytes. The classification of the cell size was shiftet to greater diameters in comparison with healthy donors. The evaluation of the biological half time of erythrocytes labelled with 51Cr resulted in a decrease of about 16 days. The autoradiographic evaluation of the erythrocyte size-distribution patterns 1 and 24 hours after the injection of labelled red cells into the donors circulation clearly demonstrated a decrease of macro- and megalocytes. Simultaneously, the number of microcytes rose considerably. The measurement of erythrocyte deformability could demonstrate a clearcut relationship of flexibility for a) disturbed erythropoiesis resulting in the production of macro- and megalocytes, and b) fragmentation and premature elimination from the circulation due to unfavourable rheologic properties of erythrocytes of abnormal big and small sizes.
该研究关注的是可能缩短间歇性血液透析患者红细胞寿命的因素。这些患者的红细胞群体包括小红细胞、正常红细胞、大红细胞和巨红细胞。与健康献血者相比，这些患者的细胞大小分类向更大直径偏移。对用51Cr标记的红细胞的生物学半衰期进行评估，结果显示减少了约16天。将标记红细胞注入献血者循环后1小时和24小时对红细胞大小分布模式进行放射自显影评估，清楚地显示大红细胞和巨红细胞数量减少。同时，小红细胞数量大幅增加。红细胞变形性的测量可以表明，对于a）导致大红细胞和巨红细胞产生的红细胞生成紊乱，以及b）由于异常大小的红细胞具有不利的流变学特性而导致的破碎和过早从循环中清除，其柔韧性存在明确的关系。
