Inauen W, Stäubli M, Descoeudres C, Galeazzi R L, Straub P W
Eur J Clin Invest. 1982 Apr;12(2):173-6. doi: 10.1111/j.1365-2362.1982.tb00955.x.
In thirty-one uraemic patients, fourteen on conservative treatment and seventeen on long-term haemodialysis, erythrocyte deformability, measured as filtration half-time in a paper filtration experiment, was studied. The two groups were comparable concerning age, sex and kidney disease. Although the mean filtration half-time for erythrocyte suspensions was normal in non-dialysed patients there was a positive linear correlation (P less than 0.01) between serum creatinine and filtration half-time in this group. Filtration half-time was increased in dialysed patients, indicating impaired deformability in the latter (P less than 0.001). Filtration half-time showed a good inverse correlation with the packed red cell volume in the non-dialysed (P less than 0.001) and in the dialysed group (P less than 0.01). As pre- and post-dialysis filtration half-times were the same, it appeared that the more severe uraemic state of dialysed patients was responsible for the impairment of erythrocyte deformability and not the dialysis procedure itself.
对31例尿毒症患者进行了研究，其中14例接受保守治疗，17例接受长期血液透析，通过滤纸过滤实验中的过滤半衰期来测定红细胞变形性。两组在年龄、性别和肾病方面具有可比性。尽管未透析患者红细胞悬液的平均过滤半衰期正常，但该组血清肌酐与过滤半衰期之间存在正线性相关（P<0.01）。透析患者的过滤半衰期增加，表明后者的变形性受损（P<0.001）。在未透析组（P<0.001）和透析组（P<0.01）中，过滤半衰期与红细胞压积呈良好的负相关。由于透析前和透析后的过滤半衰期相同，似乎是透析患者更严重的尿毒症状态导致了红细胞变形性受损，而不是透析过程本身。
