Pedersen N T
Scand J Haematol. 1978 Nov;21(5):369-75. doi: 10.1111/j.1600-0609.1978.tb00381.x.
A total of 17 patients with hypertension undergoing renal vein or adrenal vein catheterization were investigated in order to ascertain the number of megakaryocytes in blood from the inferior vena cava, the femoral artery and a cubital vein. On an average 11.9, 3.8, and 4.5 megakaryocytes per ml were found, respectively. In blood from the inferior vena cava, 30% of the megakaryocytes had copious cytoplasm, while megakaryocytes in arterial and cubital venous blood had sparse or no visible cytoplasm. It was demonstrated that 2/3 of the megakaryocytes were retained in the pulmonary circulation and that at least 70% of the platelets could derive from megakaryocytes in central venous blood or the pulmonary circulation. It was found that megakaryocytes pass through a life cycle in which the differentiation take place in the bone marrow, platelet release occurs mainly in central venous blood and in the pulmonary circulation and the destruction of the megakaryocyte nucleus take place outside the bone marrow, especially in the pulmonary circulation.
为确定下腔静脉、股动脉和肘静脉血中的巨核细胞数量，对17例接受肾静脉或肾上腺静脉导管插入术的高血压患者进行了研究。平均每毫升分别发现11.9、3.8和4.5个巨核细胞。在下腔静脉血中，30%的巨核细胞有丰富的细胞质，而动脉血和肘静脉血中的巨核细胞细胞质稀少或不可见。结果表明，2/3的巨核细胞保留在肺循环中，至少70%的血小板可来源于中心静脉血或肺循环中的巨核细胞。研究发现，巨核细胞经历一个生命周期，其中分化在骨髓中发生，血小板释放主要发生在中心静脉血和肺循环中，巨核细胞核的破坏发生在骨髓外，尤其是在肺循环中。
