Heymann W, Boxerbaum B, Makker S
Int J Pediatr Nephrol. 1980 Mar;1(1):4-9.
A.S.O. titers were determined in 93 children with various kidney diseases. In addition, 52 children without renal disorders were investigated as controls. In the children with renal disease, 38 suffered from the "idiopathic", "primary" nephrotic syndrome of childhood. Thirteen had acute, post-infectious glomerulonephritis, 16 had "primary" chronic glomerulonephritis, 3 had pyelonephritis, and 1 had disseminated lupus nephritis. In acute glomerulonephritis, with or without N.S., the titers were higher than in the controls, which is known and consistent with the frequency of preceding streptococcal infections. Children with chronic glomerulonephritis, with and without associated N.S., did not show a similar tendency to increased values. All patients but one with "primary", , "idiopathic" N.S. of childhood had titers of less than 100. They were between 50 and 12 Todd units. These titers were observed early during the course of the disease and persisted for years in spite of remissions. They were not related to concomitant antimicrobial therapy, nor to corticosteroid administration. In "idiopathic" nephrotic syndrome of childhood a titer of less than 100 does not, in itself, lead to the diagnosis of a N.S. of childhood. However, a greater than 100 titer speaks against it and may well serve as a valid indication for a renal biopsy, in order to differentiate this disease from acute glomerulonephritis, and also from R.P.G.N. whenever they are associated with a N.S. The low titers are only of value in differentiating the "primary" form of the N.S. from the "secondary" forms which are preceded by chronic renal disease or which are due to another underlying, systemic disease. In nephrotic children less than 6 years of age, the less than 100 A.S.O. titers may also be due to their age.
对93名患有各种肾脏疾病的儿童测定了抗链球菌溶血素O（A.S.O.）效价。此外，对52名无肾脏疾病的儿童进行了调查作为对照。在患有肾脏疾病的儿童中，38名患有儿童“特发性”“原发性”肾病综合征。13名患有急性感染后肾小球肾炎，16名患有“原发性”慢性肾小球肾炎，3名患有肾盂肾炎，1名患有弥漫性狼疮性肾炎。在急性肾小球肾炎中，无论有无肾病综合征，效价均高于对照组，这是已知的，且与先前链球菌感染的频率一致。患有慢性肾小球肾炎的儿童，无论有无相关肾病综合征，均未表现出类似的升高趋势。除1名患有儿童“原发性”“特发性”肾病综合征的患者外，所有患者的效价均低于100。效价在50至12托德单位之间。这些效价在疾病过程早期即被观察到，尽管病情缓解仍持续数年。它们与同时进行的抗菌治疗无关，也与皮质类固醇给药无关。在儿童“特发性”肾病综合征中，效价低于100本身并不能诊断儿童肾病综合征。然而，效价大于100则可排除该病，并且很可能作为进行肾活检的有效指征，以便将该疾病与急性肾小球肾炎以及与肾病综合征相关时的急进性肾小球肾炎相鉴别。低效价仅在区分肾病综合征的“原发性”形式与由慢性肾脏疾病引起或由另一种潜在的全身性疾病导致的“继发性”形式时有价值。在6岁以下的肾病儿童中，A.S.O.效价低于100也可能与其年龄有关。
