Buri P, Doelker E, Boucherat J
J Clin Hosp Pharm. 1981 Jun;6(2):101-5. doi: 10.1111/j.1365-2710.1981.tb00981.x.
This study consisted of a comparison of the release rates of six commercial brands of prolonged-release vincamine. The pH of the dissolution medium was found to be highly significant. Due to the low solubility of vincamine in media close to the neutral point, all of the preparations tested, with the exception of one, showed highly variable release curves under the three pH conditions chosen.
本研究对六种市售长春胺缓释制剂的释放速率进行了比较。发现溶出介质的pH值具有高度显著性。由于长春胺在接近中性点的介质中溶解度较低，除一种制剂外，所有受试制剂在所选的三种pH条件下均显示出高度可变的释放曲线。
