Wintermantel E, Heller W
Neurochirurgia (Stuttg). 1981 Jul;24(4):115-8. doi: 10.1055/s-2008-1053858.
Experiments with Wistar rats have been performed in order to analyse brain and liver metabolism after suturing of the rats right carotid artery. It should be figured out how much an interruption of the bilateral blood supply of the brain during end-to-end-anastomosis of a carotid artery would interfere with normal brain and liver metabolism. General anaesthesia of all animals was obtained with pentobarbital. The vascular anastomoses have been performed by using the microsurgical technique. Groups of animals were formed in order to analyse metabolism after various periods of postoperative survival. Brain and liver tissue was removed and the metabolism stopped immediately by freezing the tissue in liquid nitrogen. Biochemical analysis showed several highly significant changes of levels of values indicating hypoxia. Additional experiments have been carried out in order to find out whether hypoxia could be detected in other organs of the body such as the liver after performing the same microsurgical procedure on a carotid artery and how pronounced these changes would be compared to those of brain metabolism. Results of experiments performed up to now indicate that hypoxia also develops in liver tissue.
为了分析大鼠右颈动脉缝合后脑和肝脏的代谢情况，我们用Wistar大鼠进行了实验。应当弄清楚在颈动脉端端吻合术中，脑双侧血液供应中断会在多大程度上干扰正常的脑和肝脏代谢。所有动物均用戊巴比妥进行全身麻醉。血管吻合采用显微外科技术完成。为了分析术后不同存活期的代谢情况，将动物分组。取出脑和肝脏组织，并通过将组织置于液氮中冷冻，立即停止代谢。生化分析显示，表明缺氧的各项指标水平有若干高度显著的变化。我们还进行了额外的实验，以确定在对颈动脉进行相同的显微外科手术后，是否能在身体的其他器官（如肝脏）中检测到缺氧，以及与脑代谢的变化相比，这些变化会有多明显。到目前为止所做实验的结果表明，肝脏组织中也会出现缺氧情况。
