Del Gado R, Polito C, Strano C G, Di Toro R
Pediatr Med Chir. 1981 Sep-Oct;3(5):399-401.
In 52 out of 272 children with one of the following diseases: nephrotic or nephritic syndrome, persistent humaturia and/or proteinuria, renal biopsy was performed on the basis of commonly accepted indications. 18 biopsies were from patients with a clinical picture of lipoid nephrosis and clinical course of "non responders" or "frequent relapsers" types. All of them showed the histologic pattern of minimal changes and had a value of Y index according to ISKCD greater than 0,85. Moreover all patients with minimal changes nephrotic syndrome had a Y index greater than 0.85. If these observations will be confirmed renal biopsy would not later be indicated in children with "lipoid nephrosis".
在272名患有以下疾病之一的儿童中,有52名:肾病综合征或肾炎综合征、持续性血尿和/或蛋白尿,根据普遍认可的指征进行了肾活检。18例活检取自具有类脂性肾病临床表现且临床病程为“无反应者”或“频繁复发者”类型的患者。所有这些患者均表现出微小病变的组织学模式,并且根据ISKCD的Y指数值大于0.85。此外,所有微小病变肾病综合征患者的Y指数均大于0.85。如果这些观察结果得到证实,那么对于患有“类脂性肾病”的儿童,以后将不再建议进行肾活检。