Ponomarkov V, Tomatis L
Scand J Work Environ Health. 1978;4 Suppl 2:127-35.
Styrene monomer dissolved in olive oil was given orally to female O20 mice (1,350 mg/kg), C57 Bl mice (300 mg/kg) and BD IV rats (1,350 mg/kg) on the 17th day of gestation. Their offspring were treated weekly with styrene by stomach tube from the time of weaning throughout their life-span. The weekly doses used were 1,350 mg/kg for O20 mice, 300 mg/kg for C57 Bl mice, and 500 mg/kg for BD IV rats. Following the continuous oral administration of styrene for over 100 weeks, an increased and earlier appearance of lung tumors was observed in O20 mice. A few tumors rarely seen in controls were observed in BD IV styrene-treated rats, and a slightly increased incidence of liver tumors was found in C57 Bl mice. In both cases, however, the total incidence of tumors was not significantly different from that of the controls. The present results provide weak evidence of the carcinogenicity of styrene in one of the two strains of mice tested, when it is given at a high dose level.
在妊娠第17天，将溶解于橄榄油中的苯乙烯单体经口给予雌性O20小鼠（1350毫克/千克）、C57 Bl小鼠（300毫克/千克）和BD IV大鼠（1350毫克/千克）。从断奶时起直至其整个寿命期，每周通过胃管给它们的后代施用苯乙烯。所使用的每周剂量分别为：O20小鼠1350毫克/千克、C57 Bl小鼠300毫克/千克、BD IV大鼠500毫克/千克。在连续口服苯乙烯超过100周后，观察到O20小鼠肺部肿瘤出现增加且出现时间提前。在经苯乙烯处理的BD IV大鼠中观察到少数在对照组中罕见的肿瘤，在C57 Bl小鼠中发现肝脏肿瘤的发生率略有增加。然而，在这两种情况下，肿瘤的总发生率与对照组相比均无显著差异。本研究结果提供了弱证据，表明在高剂量水平给予苯乙烯时，在所测试的两种小鼠品系中的一种中具有致癌性。
