[白鼠对刚地弓形虫的自然适应性]
[Natural adaptation of the white rat to Toxoplasma gondii].
作者信息
Chinchilla M, Alfaro M, Guerrero O M
出版信息
Rev Biol Trop. 1981 Dec;29(2):273-82.
White rats were found to be resistant to 3 x 10(7) Toxoplasma gondii organisms (RH strain) inoculated either sc or ip. That resistance was age-dependent since survival time of 1- or 5-day-old rats inoculated with 10(4) or 10(6) tachyzoites was lower as compared with those 10 or 15 days old. Organisms kept in contact with a lysate of white rat complete peritoneal exudate showed reduced capacity to infect mice. Peritoneal exudate of 5-day-old rats showed a stronger effect than that of 1, 2, 3, or 4 day-infected animals. After 10 days the anti-toxoplasma effect diminished and it almost disappeared after 15 days of infection. Apparently age and macrophage activity are very important factors in the natural adaptability of the white rat to Toxoplasma gondii.
发现白色大鼠对皮下或腹腔接种3×10⁷刚地弓形虫（RH株）具有抗性。这种抗性与年龄有关，因为接种10⁴或10⁶速殖子的1日龄或5日龄大鼠的存活时间比10日龄或15日龄的大鼠短。与白色大鼠完全腹膜渗出液裂解物接触的生物体感染小鼠的能力降低。5日龄大鼠的腹膜渗出液比1、2、3或4日龄感染动物的渗出液具有更强的作用。10天后抗弓形虫作用减弱，感染15天后几乎消失。显然，年龄和巨噬细胞活性是白色大鼠对刚地弓形虫自然适应性的非常重要的因素。
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