Hennessy D R, Prichard R K
Vet Res Commun. 1981 Sep;5(1):45-9. doi: 10.1007/BF02214966.
Comparisons were made of the relative efficacy of ozfendazole (OFZ), administered to sheep at 5 mg/kg either as an oral drench, single intravenous injection or 12 and 24 divided intravenous injections over 24 and 48 hours, against benzimidazole-resistant Haemonchus contortus and Trichostrongylus colubriformis. A single intravenous injection was at least equally potent as the oral drench whilst the divided dose intravenous regimes significantly increased OFZ efficacy against both parasite species. These findings demonstrate that (i) absorbed drug is important for the efficacy of OFZ against nematodes in the abomasum and small intestine and may be more important than unabsorbed drug passing down the gastrointestinal tract, and (ii) the maintenance of plasma OFZ levels of approximately 2 micrograms/ml by divided dose regime increased efficacy compared with that achieved with the same total dose given as a single administration.
对奥芬达唑（OFZ）以5毫克/千克的剂量对绵羊进行给药的相对疗效进行了比较，给药方式分别为口服灌服、单次静脉注射或在24小时和48小时内分12次和24次静脉注射，用于对抗对苯并咪唑耐药的捻转血矛线虫和蛇形毛圆线虫。单次静脉注射的效力至少与口服灌服相当，而分次静脉给药方案显著提高了OFZ对两种寄生虫的疗效。这些发现表明：（i）吸收的药物对OFZ在皱胃和小肠中对抗线虫的疗效很重要，可能比通过胃肠道下行的未吸收药物更重要；（ii）与单次给药相同总剂量相比，分次给药方案使血浆OFZ水平维持在约2微克/毫升可提高疗效。
