Kostov G
Vet Med Nauki. 1981;18(9):3-8.
Studies were carried out to obtain an allergen of Salmonella abortus ovis and establish its chemical composition and diagnostic value with guinea pigs and sheep infected with the same causative agent. It was found that the allergen produced contained a great amount of protein (75 per cent), an essentially low amount of sugars (11 per cent), and a negligible amount of total phosphorus (0.85 per cent). It was also established that the allergen did not induce the production of antibodies in rabbits following intravenous inoculation, and did not give any positive allergic reaction in normal guinea pigs after intradermal application. It was shown to have a high diagnostic value, detecting some 87 per cent of the infected guinea pigs and 85 per cent of the infected sheep. The allergen also showed high specificity - it did not induce a positive skin reaction in guinea pigs infected with Y. enterocoli type 9, E. coli, and S. cholerae suis.
开展了多项研究,以获取绵羊流产沙门氏菌的一种变应原,并确定其化学组成以及对感染相同病原体的豚鼠和绵羊的诊断价值。结果发现,所产生的变应原含有大量蛋白质(75%)、极低量的糖类(11%)以及可忽略不计的总磷量(0.85%)。还确定该变应原经静脉接种后不会在兔子体内诱导抗体产生,皮内应用后在正常豚鼠中也不会产生任何阳性过敏反应。结果表明它具有很高的诊断价值,能检测出约87%的感染豚鼠和85%的感染绵羊。该变应原还显示出高特异性——它不会在感染9型小肠结肠炎耶尔森氏菌、大肠杆菌和猪霍乱沙门氏菌的豚鼠中诱导阳性皮肤反应。