[Transmission of a delayed allergic reaction to Salmonella abortus-ovis via the blood plasma of gamma-irradiated guinea pigs].

Use was made of blood plasma taken from guinea pigs (sensibilized with a live culture of Salmonella abortus ovis and then irradiated wiht 800 rad gamma-rays) to transmit the skin allergy reaction to normal, nonsensibilized guinea pigs. The allergy reaction was demonstrated in the recipients of plasma as early as the 3-4th hour following the injection of the allergen into the skin. It reached its peak at the 12-24th hour and later on strongly diminished, remaining in few of the animals only up to the 48th hour. The infiltrate at the site of injection in the skin of positively reacting animals contained at the 24th hour cells of the polymorphonuclear type which predominated, while the cells of the mononuclear type were few in number. There were no precipitins in the plasma of the donors, and the titer of the agglutinins and the cytophile antibodies was very low. Regardless of these findings it was concluded that the transmitted allergy reaction was of the fast type (after Arthuss), and not of the delayed one.