Singer D R, Markandu N D, Shore A C, MacGregor G A
Department of Medicine, Charing Cross and Westminster Medical School, London, UK.
J Hum Hypertens. 1987 Jun;1(1):31-7.
In a randomised, crossover study of patients with moderate to severe essential hypertension, the effects of the calcium entry antagonist nifedipine and the beta-receptor blocking drug acebutolol were studied on their own, and in combination. After 4 weeks of nifedipine tablets 20 mg twice daily (Adalat, Bayer), mean supine blood pressure (BP) fell by 20 mmHg and after 4 weeks of acebutolol 200 mg twice a day (Sectral, May & Baker) by 11 mmHg. When nifedipine and acebutolol were given in combination in the above doses for 4 weeks, there was a significantly greater fall in BP than with either agent alone, supine mean arterial pressure falling by 27 mmHg. The above BPs were measured 2 h after the last dose of tablets. Measurements 12 h after the last dose showed smaller falls in BP, with a significantly greater fall with combination treatment than with acebutolol alone. The fall in BP 12 h after the last dose of the combination was greater than with nifedipine alone but this difference was not statistically significant. This randomised, controlled study showed that nifedipine and acebutolol have a marked additive effect on BP which is sustained for at least 12 h after treatment.
在一项针对中度至重度原发性高血压患者的随机交叉研究中，对钙通道拮抗剂硝苯地平和β受体阻滞剂醋丁洛尔单独使用及联合使用的效果进行了研究。在每日两次服用20毫克硝苯地平片（拜耳公司的拜新同）4周后，平均仰卧血压下降了20毫米汞柱；在每日两次服用200毫克醋丁洛尔（美澳健公司的 Sectral）4周后，平均仰卧血压下降了11毫米汞柱。当按上述剂量联合使用硝苯地平和醋丁洛尔4周时，血压下降幅度明显大于单独使用任何一种药物，仰卧平均动脉压下降了27毫米汞柱。上述血压值在最后一剂片剂服用2小时后测量。最后一剂服用12小时后的测量结果显示，血压下降幅度较小，联合治疗的下降幅度明显大于单独使用醋丁洛尔。联合用药最后一剂服用12小时后的血压下降幅度大于单独使用硝苯地平，但这种差异无统计学意义。这项随机对照研究表明，硝苯地平和醋丁洛尔对血压有显著的相加作用，且在治疗后至少12小时内持续存在。
