Libiszewski D
J Clin Hosp Pharm. 1981 Mar;6(1):39-49. doi: 10.1111/j.1365-2710.1981.tb00885.x.
The dosage of nephrotoxic drugs such as gentamicin should ideally be adjusted when they are administered to patients with varying degrees of renal impairment. Such as adjustment of dosage should be estimated with a knowledge of the plasma levels of the drug. Until regular monitoring of drug levels of plasma is routinely available, the use of nomograms which utilize pharmacokinetic data quoted in the literature would provide dosage regimens tailored to suit the individual need of the renal patients. A service for dosage adjustment of nephrotoxic drugs has been provided in the Macclesfield Health District since December 1977 and has been well received by prescribers in the hospitals. The use of flow chart scheme for the adjustment of individual dosage for routine use is described. About 80% of the requests were for dosage adjustments of gentamicin in renal failure. It is advocated that such a service can be provided by hospital pharmacists without difficulty and should be encouraged as part of the patient services.
当向不同程度肾功能损害的患者使用庆大霉素等肾毒性药物时，理想情况下应调整其剂量。这种剂量调整应根据药物血浆水平的知识进行估算。在常规进行血浆药物水平监测之前，使用利用文献中引用的药代动力学数据的列线图将提供适合肾病患者个体需求的给药方案。自1977年12月以来，麦克尔斯菲尔德健康区一直提供肾毒性药物剂量调整服务，并受到医院开方者的好评。本文描述了用于常规调整个体剂量的流程图方案。约80%的请求是针对肾衰竭患者庆大霉素的剂量调整。有人主张，医院药剂师可以毫无困难地提供这种服务，并且作为患者服务的一部分应予以鼓励。
