Plouin P, Sternberg B, Bour F, Lerique A
Rev Electroencephalogr Neurophysiol Clin. 1981 Dec;11(3-4):385-9. doi: 10.1016/s0370-4475(81)80075-5.
Forty-three neonates with status epilepticus of unidentified etiology were studied by EEG. 90% had favorable outcome. In the cases with unfavorable evolution the following criteria allowed an early poor prognosis: a very early onset of the seizures in the first or second day of life, the presence of tonic seizures and hypertony between seizures, duration of the seizures more than 4 days, EEG activity in the frequency of the alpha band during the seizures, a flat tracing after the seizures, very discontinuous activity between the seizures and, finally, the reappearance of seizures after a seizure-free interval. In the cases of favorable outcome, an EEG follow-up is necessary: in 10% of these cases focal spikes appeared after 2 years without seizures. The necessity of prolonged anti-comital treatment is discussed.
对43例病因不明的新生儿癫痫持续状态患儿进行了脑电图研究。90%的患儿预后良好。在病情进展不佳的病例中,以下标准提示早期预后不良:在出生后第一天或第二天很早即出现癫痫发作、存在强直发作以及发作间期肌张力亢进、癫痫发作持续时间超过4天、癫痫发作时出现α波频段的脑电图活动、发作后脑电图呈平线、发作间期脑电图活动极不连续,最后,在无癫痫发作间期后癫痫再次发作。在预后良好的病例中,有必要进行脑电图随访:其中10%的病例在无癫痫发作2年后出现局灶性棘波。文中还讨论了延长抗惊厥治疗的必要性。