Saxena R C, Thacore V R, Suri M L, Agarwal T N, Bhargava K P
Electroencephalogr Clin Neurophysiol. 1977 Dec;43(6):876-9. doi: 10.1016/0013-4694(77)90010-4.
Methaqualone injected i.v. has been reported to be a safe short-acting anaesthetic agent and a muscle relaxant in man. It has been employed in a variety of operative procedures and to modify convulsions in the management of tetanus and in electroconvulsive therapy. Safety, usefulness and the marked central effects of the drug led us to study its central effects by EEG in man. Discrepancies between clinical and EEG signs were thus seen. EEG patterns resembled those after barbiturates and the effect was dose dependent. Differences between methaqualone and barbiturates are discussed. The EEG patterns were potentiated by thioridazine and antagonised by imipramine.
据报道，静脉注射甲喹酮在人体中是一种安全的短效麻醉剂和肌肉松弛剂。它已被用于各种手术程序，并用于治疗破伤风和电休克治疗中的惊厥。该药物的安全性、有效性以及显著的中枢作用促使我们通过脑电图研究其在人体中的中枢作用。因此发现了临床体征和脑电图体征之间的差异。脑电图模式类似于巴比妥类药物后的模式，且效果呈剂量依赖性。讨论了甲喹酮和巴比妥类药物之间的差异。硫利达嗪可增强脑电图模式，而丙咪嗪可拮抗该模式。
