Methaqualone pharmacokinetics after single- and multiple-dose administration in man.

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作者信息

Nayak R K, Smyth R D, Chamberlain J H, Polk A, DeLong A F, Herczeg T, Chemburkar P B, Joslin R S, Reavey-Cantwell N H

出版信息

J Pharmacokinet Biopharm. 1974 Apr;2(2):107-21. doi: 10.1007/BF01061503.

DOI:10.1007/BF01061503

PMID:4427217

Abstract

摘要

相似文献

Methaqualone pharmacokinetics after single- and multiple-dose administration in man.

J Pharmacokinet Biopharm. 1974 Apr;2(2):107-21. doi: 10.1007/BF01061503.

Plasma concentrations and effects of methaqualone after single and multiple oral doses in man.甲喹酮单次及多次口服给药后在人体中的血浆浓度及效应

Eur J Clin Pharmacol. 1974 Oct 4;7(6):449-54. doi: 10.1007/BF00560357.

Plasma kinetics of methaqualone in man after single oral doses.单次口服剂量后甲喹酮在人体中的血浆动力学。

Eur J Clin Pharmacol. 1973 Oct;6(3):187-90. doi: 10.1007/BF00558284.

Hypnotic and hypothermic responses following chronic administration of methaqualone in the rat.大鼠长期服用甲喹酮后的催眠和体温过低反应。

Res Commun Chem Pathol Pharmacol. 1973 Jul;6(1):101-8.

Absorption and clearance of secobarbital, heptabarbital, methaqualone, and ethinamate.司可巴比妥、庚巴比妥、甲喹酮及炔己蚁胺的吸收与清除

Clin Pharmacol Ther. 1974 Aug;16(2):376-89. doi: 10.1002/cpt1974162376.

Bioavailability of methaqualone.甲喹酮的生物利用度。

J Clin Pharmacol. 1973 Oct;13(10):391-400. doi: 10.1002/j.1552-4604.1973.tb00185.x.

Plasma levels and absorption of methaqualone after oral administration to man.口服甲喹酮后人体血浆中的药物水平及吸收情况。

Clin Pharmacol Ther. 1972 Sep-Oct;13(5):719-23. doi: 10.1002/cpt1972135part1719.

Variation in biological availability.生物利用度的变化。

Lancet. 1973 Feb 24;1(7800):440. doi: 10.1016/s0140-6736(73)90316-4.

Prediction of drug oxidation rates in man: lack of correlation with serum gamma-glutamyl transpeptidase and urinary excretion of D-glucaric acid and 6 beta-hydroxycortisol.人体药物氧化速率的预测：与血清γ-谷氨酰转肽酶以及D-葡萄糖醛酸和6β-羟基皮质醇尿排泄量缺乏相关性。

Eur J Clin Pharmacol. 1974;7(1):71-5. doi: 10.1007/BF00614394.

Proceedings: Pharmacokinetics and biotransformation of 2-methyl-3-(4'-chlorphenyl)-4-oxo-3,4-dihydropyrido[2.3-d]pyrimidine(I), an aza analogue of methaqualone (II).论文：2-甲基-3-(4'-氯苯基)-4-氧代-3,4-二氢吡啶并[2.3-d]嘧啶（I）的药代动力学及生物转化，甲喹酮（II）的氮杂类似物

Acta Pharm Suec. 1974 Dec;11(6):645-6.

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The kinetics of the urinary excretion of the N-oxide and glucuronides of methaqualone in man.

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The influence of the menstrual cycle on the metabolism and clearance of methaqualone.月经周期对甲喹酮代谢及清除率的影响。

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Clinical implications of enzyme induction and enzyme inhibition.酶诱导和酶抑制的临床意义。

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Critical compilation of terminal half-lives, percent excreted unchanged, and changes of half-life in renal and hepatic dysfunction for studies in humans with references.对人类研究中终末半衰期、原形药物排泄百分比以及肾功能和肝功能不全时半衰期变化进行批判性汇编，并列出参考文献。

J Pharmacokinet Biopharm. 1975 Oct;3(5):333-83. doi: 10.1007/BF01082306.

Comparison of the pharmacokinetics of diazepam after single and subchronic doses.单次和亚慢性剂量后地西泮的药代动力学比较。

Eur J Clin Pharmacol. 1976 Jun 15;10(2):121-6. doi: 10.1007/BF00609470.

Long-term urinary excretion of methaqualone in a human subject.一名人类受试者中长期甲喹酮的尿液排泄情况。

J Pharmacokinet Biopharm. 1978 Apr;6(2):111-22. doi: 10.1007/BF01117446.

Inter- and intra-individual variation in the metabolism of methaqualone in man after a single oral dose.单次口服剂量后，人对甲喹酮代谢的个体间和个体内差异。

Eur J Clin Pharmacol. 1978 Jun 19;13(4):291-7. doi: 10.1007/BF00716365.

The effect of assay methods on plasma levels and pharmacokinetics of theophylline: HPLC and EIA.检测方法对茶碱血浆浓度及药代动力学的影响：高效液相色谱法与酶免疫分析法

Br J Clin Pharmacol. 1979 Apr;7(4):333-41. doi: 10.1111/j.1365-2125.1979.tb00942.x.

本文引用的文献

Metabolism of d-glucuronolactone in mammalian systems. Identification of d-glucaric acid as a normal constituent of urine.d-葡糖醛酸内酯在哺乳动物系统中的代谢。鉴定d-葡萄糖二酸为尿液的正常成分。

Biochem J. 1963 Jan;86(1):77-86. doi: 10.1042/bj0860077.

Effect of chronic treatment of methaqualone on the turnover of hexobarbital and methaqualone in rats.长期使用甲喹酮对大鼠体内己巴比妥和甲喹酮代谢转换的影响。

Indian J Med Sci. 1967 Aug;21(8):524-32.

Stimulation of drug metabolism by centrally active drugs.中枢活性药物对药物代谢的刺激作用。

Br J Pharmacol. 1971 Feb;41(2):383P.

Drug-metabolizing capacity in states of drug dependence and withdrawal.药物依赖和戒断状态下的药物代谢能力。

Br J Pharmacol. 1972 Aug;45(4):638-43. doi: 10.1111/j.1476-5381.1972.tb08122.x.

An improved quantitative gas-liquid chromatographic assay for the estimation of methaqualone in biological fluids.一种用于测定生物体液中安眠酮的改良定量气液色谱分析法。

J Chromatogr. 1972 Oct 5;72(1):29-34. doi: 10.1016/0021-9673(72)80005-0.

Intravenous methaqualone: a new non-barbiturate anaesthetic.静脉注射安眠酮：一种新型非巴比妥类麻醉剂。

Br J Anaesth. 1972 Jan;44(1):83-5. doi: 10.1093/bja/44.1.83.

Plasma levels and absorption of methaqualone after oral administration to man.口服甲喹酮后人体血浆中的药物水平及吸收情况。

Clin Pharmacol Ther. 1972 Sep-Oct;13(5):719-23. doi: 10.1002/cpt1972135part1719.

Sedative--hypnotics.镇静催眠药。

Anesthesiology. 1971 Feb;34(2):170-82.

Urinary D-glucaric acid excretion and total liver content of cytochrome P-450 in guinea-pigs: relationship during enzyme induction and following inhibition of protein synthesis.豚鼠尿中D-葡糖二酸排泄及细胞色素P-450的肝脏总含量：酶诱导及蛋白质合成抑制过程中的关系

Biochem Pharmacol. 1973 Mar 15;22(6):743-7. doi: 10.1016/0006-2952(73)90405-x.

Methaqualone: metabolic, kinetic, and clinical pharmacologic observations.甲喹酮：代谢、动力学及临床药理学观察

Clin Pharmacol Ther. 1973 May-Jun;14(3):314-24. doi: 10.1002/cpt1973143314.

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