Susilowati S, Okuno Y, Fukunaga T, Tadano M, Juang R F, Fukai K
Biken J. 1981 Dec;24(4):137-45.
Single doses of Japanese encephalitis (JE) vaccine of the Nakayama strain were given to members of the staffs of a hospital and 99 paired-sera were obtained. Neutralization antibody titers of the sera were determined against the Nakayama strain and E-50 strain, isolated from wild Culex tritaeniorhynchus using clone C6/36 of Singh's Aedes albopictus mosquito cell culture. Post-vaccination sera showed a significant neutralizing antibody response against both the Nakayama and E-50 strain. The geometrical mean neutralization titers of post-vaccination sera against the Nakayama and E-50 strains were in the same order, although the geometrical mean neutralization titer against the Nakayama strain was the higher in pre-vaccination sera. The antibody responses against the Nakayama strain and E-50 strain were somewhat different in detail: 7 individuals with a pre-vaccination neutralization titers of less than 10 showed antibody responses to the Nakayama strain, whereas 3 individuals of the same group did not show any detectable response to the E-50 strain.
给一家医院的工作人员接种了单剂量的中山株日本脑炎（JE）疫苗，并获得了99份配对血清。使用辛格白纹伊蚊C6/36克隆，测定了这些血清针对中山株和从野生三带喙库蚊分离出的E-50株的中和抗体效价。接种疫苗后的血清对中山株和E-50株均显示出显著的中和抗体反应。接种疫苗后的血清针对中山株和E-50株的几何平均中和效价顺序相同，尽管接种疫苗前血清针对中山株的几何平均中和效价更高。针对中山株和E-50株的抗体反应在细节上有所不同：接种疫苗前中和效价低于10的7人对中山株有抗体反应，而同一组中的3人对E-50株未显示任何可检测到的反应。
