Wheeler K T
Cancer Treat Rep. 1981;65 Suppl 2:75-81.
This review summarizes the problems and pitfalls encountered when increased life span studies are performed with brain tumor model systems. The biological factors reviewed include tumor size and growth rate, the immune response, cell kinetics, and cell recovery processes. The analytical factors reviewed include data collection, data presentation, covariate analysis, and statistical analysis. Examples of how these factors can influence the ultimate interpretation of results from brain tumor therapy trials are presented.
本综述总结了在使用脑肿瘤模型系统进行寿命延长研究时遇到的问题和陷阱。所综述的生物学因素包括肿瘤大小和生长速率、免疫反应、细胞动力学以及细胞恢复过程。所综述的分析因素包括数据收集、数据呈现、协变量分析和统计分析。文中给出了这些因素如何影响脑肿瘤治疗试验结果最终解读的示例。
