Marton L J
Med Biol. 1981 Dec;59(5-6):458-61.
Polyamine biosynthesis inhibition is being studied intensively as a new approach to cancer chemotherapy. In order to utilize appropriately compounds that deplete intracellular levels of polyamines, the effects of polyamines depletion on tumor and normal cell growth and the interaction of these inhibitors with chemotherapeutic agents must be understood. These topics are discussed briefly with respect to the general rationale for the treatment of brain tumors, and a number of potential advantages and disadvantages of the use of polyamine biosynthesis inhibitors in cancer chemotherapy protocols are discussed.
多胺生物合成抑制作为一种癌症化疗的新方法正在被深入研究。为了合理利用能降低细胞内多胺水平的化合物，必须了解多胺耗竭对肿瘤和正常细胞生长的影响以及这些抑制剂与化疗药物的相互作用。就脑肿瘤治疗的一般基本原理简要讨论了这些主题，并探讨了在癌症化疗方案中使用多胺生物合成抑制剂的一些潜在优缺点。
