Golden D B, Kagey-Sobotka A, Valentine M D, Lichtenstein L M
J Allergy Clin Immunol. 1981 Jun;67(6):482-4. doi: 10.1016/0091-6749(81)90102-0.
To decrease the cost, inconvenience, and potential side effects of venom immunotherapy we tested whether the interval between the maintenance injections can be increased. In 30 patients who had been given the standard therapy regimen and who had been sting-challenged after 1 and 2 yr of monthly maintenance injections the maintenance interval was increased from 4 to 6 wk. IgG anti-yellow jacket venom antibodies did not change over the next 9 mo. The incidence of local reactions to venom injections did not increase, and there were no systemic reactions during therapy. After 6 to 9 mo 29 of the 30 patients were sting-challenged with one possible reaction. The success rate, 97%, is the same as that observed with monthly maintenance injections. We conclude that the 6-wk maintenance interval is effective in both clinical and immunologic terms after a period of monthly maintenance therapy.
为降低毒液免疫疗法的成本、不便之处及潜在副作用，我们测试了维持注射之间的间隔时间是否可以延长。30例接受标准治疗方案的患者，在每月进行维持注射1年和2年后接受了蜂蜇激发试验，之后将维持间隔从4周延长至6周。在接下来的9个月中，IgG抗黄蜂毒液抗体没有变化。毒液注射局部反应的发生率没有增加，治疗期间也没有出现全身反应。6至9个月后，30例患者中有29例接受了蜂蜇激发试验，仅出现1例可能的反应。成功率为97%，与每月维持注射时观察到的相同。我们得出结论，在经过一段时间的每月维持治疗后，6周的维持间隔在临床和免疫学方面均有效。
