罗霍恩－比尔神经元起源于16细胞期青蛙胚胎的卵裂球。

Rohon-Beard neuron origin from blastomeres of the 16-cell frog embryo.

作者信息

Jacobson M

出版信息

J Neurosci. 1981 Aug;1(8):918-22. doi: 10.1523/JNEUROSCI.01-08-00918.1981.

DOI:10.1523/JNEUROSCI.01-08-00918.1981

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6564228/

Abstract

Clonal origins of Rohon-Beard neurons in Xenopus were determined quantitatively by injecting horseradish peroxidase into individual blastomeres at the 16-cell stage and later counting labeled and unlabeled Rohon-Beard neurons. Two different patterns of cleavage were selected. In pattern X, all Rohon-Beard neurons originated from three blastomeres (V1.1, V1.2, and V2.2) on each side; in pattern Y, all Rohon Beard neurons originated from two blastomeres (V1.2 and V2.2) on each side. Counts of Rohon-Beard neurons at larval stages 32 to 34 showed that 96 to 100% (mean 99%) originated from blastomeres on the same side; of these, 68 to 90% (mean 75%) descended from V1.2, 20 to 31% (mean 24%) descended from V2.2, 0 to 7% descended from V1.1. The significance of the regionally restricted origin of Rohon-Beard neurons is discussed.

摘要

通过在16细胞期向单个卵裂球注射辣根过氧化物酶，然后对标记和未标记的罗霍恩 - 比尔兹神经元进行计数，定量确定了非洲爪蟾中罗霍恩 - 比尔兹神经元的克隆起源。选择了两种不同的卵裂模式。在模式X中，所有罗霍恩 - 比尔兹神经元均起源于每侧的三个卵裂球（V1.1、V1.2和V2.2）；在模式Y中，所有罗霍恩 - 比尔兹神经元均起源于每侧的两个卵裂球（V1.2和V2.2）。对第32至34期幼虫阶段的罗霍恩 - 比尔兹神经元计数表明，96%至100%（平均99%）起源于同侧的卵裂球；其中，68%至90%（平均75%）来自V1.2，20%至31%（平均24%）来自V2.2，0%至7%来自V1.1。讨论了罗霍恩 - 比尔兹神经元区域受限起源的意义。

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