Kaplan S L, Mason E O
Pediatr Pharmacol (New York). 1981;1(4):305-11.
The activity of ampicillin and chloramphenicol in combination was evaluated against 16 gram-negative bacterial isolates from the cerebrospinal fluid of neonates with meningitis. The combination of antibiotics was synergistic (fractional inhibitory concentration less than 1.0) against 11 of 16 (69%) isolates by agar dilution technique and 12 of 16 (75%) isolates by microbroth dilution technique. In kinetic studies, ampicillin and chloramphenicol together exhibited an increased rate of killing against 9 of 14 isolates. Antagonistic activity between ampicillin and chloramphenicol was not demonstrated in any of the studies. The clinical evaluation of ampicillin and chloramphenicol together in the treatment of gram-negative neonatal meningitis deserves further study.
评估了氨苄西林和氯霉素联合使用对16株从患有脑膜炎的新生儿脑脊液中分离出的革兰氏阴性菌的活性。通过琼脂稀释技术，该抗生素组合对16株分离菌中的11株（69%）具有协同作用（分数抑菌浓度小于1.0），通过微量肉汤稀释技术对16株分离菌中的12株（75%）具有协同作用。在动力学研究中，氨苄西林和氯霉素联合使用对14株分离菌中的9株显示出杀菌速率增加。在任何研究中均未证明氨苄西林和氯霉素之间存在拮抗活性。氨苄西林和氯霉素联合用于治疗革兰氏阴性新生儿脑膜炎的临床评估值得进一步研究。
