Benbassat J, Hershko C, Laskov R, Eliakim M
Nutr Cancer. 1981;3(1):20-6. doi: 10.1080/01635588109513696.
The effect of iron deficiency on tumour growth and on host survival was studied in BALB/c mice with transplanted Merwin Plasma Cell-II tumors. Iron deficiency was induced by maintaining the animals on an iron-free diet consisting of milk-cornflour supplemented with CuCl2 and vitamins A and D. Iron deficiency resulted in retardation of both body and tumor growth in weanling BALB/c mice. Their survival, however, was not significantly different from that of iron supplemented controls. The inhibitory effect of iron deficiency on host and tumour growth could not be reproduced in adult BALB/c mice. The survival of tumor-bearing hosts maintained on a milk-cornflour diet (whether supplemented with iron or not) was significantly longer than that of animals maintained on a purina diet.
在移植了默温浆细胞瘤 - II 的 BALB/c 小鼠中，研究了缺铁对肿瘤生长和宿主存活的影响。通过让动物食用由添加了 CuCl₂ 以及维生素 A 和 D 的牛奶 - 玉米粉组成的无铁饮食来诱导缺铁。缺铁导致断奶的 BALB/c 小鼠的身体和肿瘤生长均迟缓。然而，它们的存活率与补充铁的对照组并无显著差异。缺铁对宿主和肿瘤生长的抑制作用在成年 BALB/c 小鼠中无法重现。以牛奶 - 玉米粉饮食喂养的荷瘤宿主（无论是否补充铁）的存活时间显著长于以普瑞纳饮食喂养的动物。
