Eipe J, Yakulis V, Costea N
Cancer Res. 1977 Oct;37(10):3551-5.
These studies examined the fate of Factor XIII (fibrin-stabilizing factor) in mice with plasmacytoma (MOPC-300, MOPC-384, MOPC-467, and J-558). Plasma Factor XIII levels in these mice decreased progressively with tumor expansion. No plasma inhibitors of Factor XIII activity could be detected. Factor XIII was found on plasmacytoma cell membranes and in the cytoplasm of the malignant cells by immunofluorescence. The inverse relationship between tumor load and plasma Factor XIII levels suggested that the fibrin-stabilizing factor was absorbed by the malignant cells.
这些研究检测了患有浆细胞瘤（MOPC - 300、MOPC - 384、MOPC - 467和J - 558）的小鼠体内因子 XIII（纤维蛋白稳定因子）的去向。随着肿瘤的发展，这些小鼠血浆中因子 XIII 的水平逐渐下降。未检测到血浆中存在因子 XIII 活性的抑制剂。通过免疫荧光法发现因子 XIII 存在于浆细胞瘤细胞膜及恶性细胞的细胞质中。肿瘤负荷与血浆因子 XIII 水平之间的负相关关系表明，纤维蛋白稳定因子被恶性细胞所吸收。
