Gilbert M, Pégorier J P
J Dev Physiol. 1981 Dec;3(6):343-54.
Weight gain, food intake and blood metabolite concentrations were investigated in conscious pregnant and non-pregnant rats. A silastic catheter was inserted under light diethyl ether anaesthesia into the carotid artery. Surgery did not significantly affect the weight gain or food intake in pregnant and non-pregnant rats compared with non-operated females. Blood glucose concentration, which was constant during the last half of pregnancy, was 1.4-fold lower than in non-pregnant rats. Blood lactate and pyruvate concentrations were similar in non-pregnant and in pregnant animals until 16.5 days of gestation. Then blood lactate concentration was increased by 50% between 16.5 days of gestation and term, whereas in the same period of pregnancy, blood pyruvate concentration was unchanged. Blood alanine concentration was increased by 150% from 13.5 days of gestation to term. Plasma non-esterified fatty acids concentration increased progressively during the second half of pregnancy to reach values 2-fold higher than in non-pregnant rats. Blood ketone bodies concentrations were unchanged during pregnancy and similar to those observed in non-pregnant animals.
对清醒的怀孕和未怀孕大鼠的体重增加、食物摄入量和血液代谢物浓度进行了研究。在轻度乙醚麻醉下，将硅胶导管插入颈动脉。与未手术的雌性大鼠相比，手术对怀孕和未怀孕大鼠的体重增加或食物摄入量没有显著影响。在怀孕的最后半个阶段血糖浓度保持恒定，比未怀孕大鼠低1.4倍。在妊娠16.5天之前，未怀孕和怀孕动物的血液乳酸和丙酮酸浓度相似。然后，在妊娠16.5天至足月期间，血液乳酸浓度增加了50%，而在同一孕期，血液丙酮酸浓度没有变化。从妊娠13.5天到足月，血液丙氨酸浓度增加了150%。在妊娠后半期，血浆非酯化脂肪酸浓度逐渐升高，达到比未怀孕大鼠高2倍的值。怀孕期间血液酮体浓度没有变化，与未怀孕动物中观察到的浓度相似。
