Spence J D, Perkins D G, Kline R L, Haust M D
Paroi Arterielle. 1981;7(4):177-87.
Hypertension may be considered a disorder of increased energy in the blood, with two components: increased pressure energy may promote arteriolar disease, whereas arterial diseases such as atherosclerosis may be more closely related to flow disturbances (turbulence, boundary layer separation, high shear, or axial stream impingement) due to increased kinetic energy. Previous studies have shown that hydralazine aggravates turbulence in stenosed carotid arteries, whereas propranolol diminishes turbulence. To assess the effect of these drugs on the progression of atherosclerosis, the drugs were administered subcutaneously to rabbits made hypertensive (one kidney Goldblatt) and hypercholesterolemic (1% cholesterol diet for 4 weeks). Appropriate controls with normal, only hypertensive and hypertensive-hypercholesterolemic untreated rabbits were employed. A total of 36 rabbits was used. The extent of the aortic surface involvement with atherosclerotic lesions was assessed by morphometric analysis of magnified photographs. Although the extent or surface involvement did not differ significantly between the untreated or treated hypertensive rabbits, there was an interesting difference in the relationship between blood pressure and extent of surface involvement. In the untreated and hydralazine treated rabbits, there was a direct correlation between increasing blood pressure and extent of lesions; in the propranolol treated group, this relationship was abolished.
高血压可被视为一种血液能量增加的病症，它有两个组成部分：压力能量增加可能会促进小动脉疾病，而诸如动脉粥样硬化等动脉疾病可能与由于动能增加导致的血流紊乱（湍流、边界层分离、高剪切力或轴向流冲击）关系更为密切。先前的研究表明，肼屈嗪会加剧狭窄颈动脉中的湍流，而普萘洛尔则会减弱湍流。为了评估这些药物对动脉粥样硬化进展的影响，将这些药物皮下注射给制成高血压（单肾Goldblatt法）和高胆固醇血症（4周1%胆固醇饮食）的兔子。使用正常、仅高血压以及高血压-高胆固醇血症未治疗兔子作为适当对照。总共使用了36只兔子。通过对放大照片进行形态计量分析来评估主动脉表面动脉粥样硬化病变的累及程度。虽然未治疗或治疗的高血压兔子之间病变累及程度或表面情况没有显著差异，但血压与表面累及程度之间的关系存在有趣的差异。在未治疗和肼屈嗪治疗的兔子中，血压升高与病变程度之间存在直接相关性；在普萘洛尔治疗组中，这种关系被消除。
