Margarido N F, Bevilacqua R G, Gonçalves E L, de Tolosa E M, Osaka J T, de Camargo M M, da Silva e Souza A H
Arq Gastroenterol. 1981 Oct-Dec;18(4):162-9.
Liver failure is a serious complication when small bowel bypass is used for control of obesity. To analyse the changes in liver microscopic morphology and liver fatty acids content, 42 rabbits divided in two groups were studied. The 21 animals of group I had 50% of the distal jejuno-ileum excluded and anastomosed to the cecum. The proximal 50% were anastomosed to the distal 5 cm of the ileum. The 21 animals of group II were used as controls and were submitted to a laparotomy and small bowel manipulation. Liver histology and fatty acids content were studied at the time of these operations and in the 21st postoperative day. No signficant histologic changes were noticed in both groups. A significant decrease in liver fatty acids content was observed in groups I and II. However, the decrease in group II was less pronounced than in group I. This last observation appears to support the theory of liver lipid metabolism impairment after small bowel bypass, even in the absence of obesity.
当采用小肠旁路手术来控制肥胖时，肝衰竭是一种严重的并发症。为了分析肝脏微观形态和肝脏脂肪酸含量的变化，对分为两组的42只兔子进行了研究。第一组的21只动物将空肠回肠远端的50%切除并与盲肠吻合。近端的50%与回肠远端5厘米处吻合。第二组的21只动物作为对照，接受剖腹术和小肠操作。在这些手术时以及术后第21天对肝脏组织学和脂肪酸含量进行了研究。两组均未观察到明显的组织学变化。第一组和第二组肝脏脂肪酸含量均显著降低。然而，第二组的降低不如第一组明显。这一最后的观察结果似乎支持了小肠旁路术后肝脏脂质代谢受损的理论，即使在没有肥胖的情况下也是如此。
