Islam N, Khan M, Ahmed Z
Bangladesh Med Res Counc Bull. 1981 Dec;7(2):45-51.
Clinical analysis of 293 cases of cirrhosis from two moderate sized hospitals in the city of Dacca has been presented. Maximum number of cases were in the age group over 40 with 150 (51.2%) males and 19 (5.8%) females. Significant past history included viral hepatitis (21.5%), kala-azar (11.6%) and malaria (10.24%). History of alcoholism was present only in 16 (5.5%) cases. Weakness (84.3%), weight loss (72%) and anorexia (39.3%) constituted the most common symptoms. Ascites (45%), haematemesis (11.6%) and melaena (28.7%) were the next common symptoms. Hepatosplenomegaly was found in about one-third of the cases. Testicular atrophy was recorded in 41.63% cases whereas gynaecomastia was relatively less common (5.5%). Scanty body hair and white nails were present in almost equal number of cases (14.7% and 18%). The cases presented here are those with overt manifestation. Nevertheless, the clinical features are not materially different from those reported by other authors. In the absence of alcoholism, viral hepatitis is presumably the most important aetiological factor in our cases and the clinical features compare favourably with non-alcoholic cirrhosis of the western writers. Cryptogenic cirrhosis has been considered to be most common type constituting 43.7% of our cases.
本文呈现了达卡市两家中等规模医院293例肝硬化病例的临床分析。病例数最多的年龄组为40岁以上，其中男性150例（51.2%），女性19例（5.8%）。重要的既往史包括病毒性肝炎（21.5%）、黑热病（11.6%）和疟疾（10.24%）。仅有16例（5.5%）有酗酒史。乏力（84.3%）、体重减轻（72%）和厌食（39.3%）是最常见的症状。腹水（45%）、呕血（11.6%）和黑便（28.7%）是其次常见的症状。约三分之一的病例有肝脾肿大。41.63%的病例有睾丸萎缩，而男性乳房发育相对较少见（5.5%）。毛发稀疏和白甲的病例数几乎相等（分别为14.7%和18%）。这里呈现的病例均为有明显临床表现的。然而，其临床特征与其他作者报道的并无实质性差异。在无酗酒情况时，病毒性肝炎可能是我们这些病例中最重要的病因，其临床特征与西方作者报道的非酒精性肝硬化相似。隐源性肝硬化被认为是最常见的类型，占我们病例的43.7%。
