Kerwar S S, Bauman N, Oronsky A L, Sloboda A E
J Immunopharmacol. 1981;3(3-4):323-37. doi: 10.3109/08923978109031065.
The effect of cobra venom factor on the developing and the established lesion of collagen-induced rat polyarthritis has been examined. In the developing lesion, decomplementation by cobra venom factor results in a delay in the onset of inflammation and a decrease in the radiological parameters of joint destruction. Under the conditions of the decomplementation, antibody titers to collagen are not decreased. In the established lesion, treatment with cobra venom factor has no effect, on either the inflammatory lesion or the various radiological parameters of joint destruction.
已研究了眼镜蛇毒因子对胶原诱导的大鼠多关节炎的发展期和已形成病变的影响。在发展期病变中，眼镜蛇毒因子导致的补体耗竭会使炎症发作延迟，关节破坏的放射学参数降低。在补体耗竭的情况下，针对胶原的抗体滴度并未降低。在已形成的病变中，用眼镜蛇毒因子治疗对炎性病变或关节破坏的各种放射学参数均无影响。
