眼镜蛇毒因子介导的补体灭活可抑制大鼠耶尔森菌诱导的关节炎。
Decomplementation by cobra venom factor suppresses Yersinia-induced arthritis in rats.
作者信息
Gaede K I, Baumeister E, Heesemann J
机构信息
Institut für Hygiene und Mikrobiologie, University of Würzburg, Germany.
出版信息
Infect Immun. 1995 Sep;63(9):3697-701. doi: 10.1128/iai.63.9.3697-3701.1995.
Abstract
Lewis rats experimentally infected with Yersinia enterocolitica O8 develop Yersinia-induced arthritis (YIA), which resembles very much reactive arthritis in humans. To investigate the involvement of serum complement in induction and maintenance of YIA, we decomplementated Yersinia-infected Lewis rats by treatment with cobra venom factor starting on day 7 after infection (prearthritic state). Reduction of serum complement activity in vivo by cobra venom factor treatment coincided with suppression of YIA clinically and histomorphologically.
摘要
实验感染小肠结肠炎耶尔森菌O8的刘易斯大鼠会患上耶尔森菌诱导的关节炎（YIA），这与人类的反应性关节炎非常相似。为了研究血清补体在YIA诱导和维持中的作用，我们在感染后第7天（关节炎前期）开始用眼镜蛇毒因子治疗，对感染耶尔森菌的刘易斯大鼠进行去补体处理。眼镜蛇毒因子处理导致体内血清补体活性降低，同时在临床和组织形态学上抑制了YIA。
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