Maj J, Daniel W, Rogóz Z, Skuza G, Sowińska H
Pol J Pharmacol Pharm. 1981;33(6):559-67.
The influence of proadifen (SKF-525-A), an agent inhibiting the metabolism of drugs, on the antidepressant action of imipramine (IMI) and desipramine (DMI) in rats was investigated. Proadifen antagonized the action of IMI when investigated in reserpine hypothermia and ptosis and in the behavioral despair test. The action of DMI in the same tests was not changed by proadifen. Proadifen lowered the level of DMI and increased the level of IMI in rat brains. The results permit to draw the conclusion that DMI plays an essential role in the action arising from IMI administration, that is, the noradrenergic--and not the serotonergic--mechanism is of essential importance.
研究了药物代谢抑制剂丙胺苯丙酮（SKF - 525 - A）对大鼠体内丙咪嗪（IMI）和地昔帕明（DMI）抗抑郁作用的影响。在利血平致体温过低和睑下垂以及行为绝望试验中研究时，丙胺苯丙酮拮抗了IMI的作用。在相同试验中，丙胺苯丙酮未改变DMI的作用。丙胺苯丙酮降低了大鼠脑中DMI的水平，提高了IMI的水平。这些结果可以得出结论，DMI在IMI给药产生的作用中起重要作用，即去甲肾上腺素能机制而非5-羟色胺能机制至关重要。
