灵长类动物肿瘤病毒SSV-1在MRC-5人二倍体细胞上的复制。
Replication of primate oncornavirus SSV-1 on MRC-5 human diploid cells.
作者信息
Horodniceanu F, Sinoussi F, Chermann J C, Tardy-Panit M, Michelson-Fiske S, Yvert F
出版信息
Dev Biol Stand. 1976;37:201-4.
PMID:73483
Abstract
MRC-5 human diploid cells infected with Simian Sarcoma Virus from woolly monkey (SSV-1) were not transformed but an efficient replication of non transforming SiLV was demonstrated. Increase of virus reverse transcriptase activity paralleled cell replication during successive passages. Preliminary results concerning the influence of viral infection on the life span and the karyotype of MRC-5 diploid cells will be reported and several implications of these findings discussed.
摘要
用来自绒毛猴的猿猴肉瘤病毒（SSV-1）感染的MRC-5人二倍体细胞未发生转化，但证实了非转化性猿猴白血病病毒（SiLV）的有效复制。在连续传代过程中，病毒逆转录酶活性的增加与细胞复制平行。将报告关于病毒感染对MRC-5二倍体细胞寿命和核型影响的初步结果，并讨论这些发现的若干意义。
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