Barenberg S A, Anderson J M, Mauritz K A
J Biomed Mater Res. 1981 Mar;15(2):231-45. doi: 10.1002/jbm.820150210.
A semiempirical epitaxial model has been derived which correlates and interrelates the surface free energy, ultrastructural morphology, surface charge, surface chemistry, and surface molecular motions of a model triblock copolymer to thrombogenesis. This paper addresses the aspect of: (1) ultrastructure order versus disorder, (2) primary and secondary molecular motions, (3) surface and side chain chemistry, (4) thrombogenesis, and (5) the derived epitaxial model based on the above observations. This model can be extrapolated to include and predict the relative thrombogenic responses of various crystalline and semicrystalline polymeric substrates, i.e., aliphatic polyolefins, polyurethanes, and polypeptides.
已推导了一个半经验外延模型，该模型将一种模型三嵌段共聚物的表面自由能、超微结构形态、表面电荷、表面化学和表面分子运动与血栓形成关联并相互联系起来。本文探讨了以下几个方面：(1) 超微结构的有序与无序；(2) 一级和二级分子运动；(3) 表面和侧链化学；(4) 血栓形成；以及(5) 根据上述观察结果得出的外延模型。该模型可以外推，以纳入并预测各种结晶和半结晶聚合物基材，即脂肪族聚烯烃、聚氨酯和多肽的相对血栓形成反应。
