Lue S L, Paronetto F, Lieber C S
Liver. 1981 Dec;1(4):264-7. doi: 10.1111/j.1600-0676.1981.tb00042.x.
Mononuclear cell cytotoxicity against autologous, allogeneic and xenogeneic (rabbit) hepatocytes was investigated in nine baboons fed alcohol for 17-21 months and in nine pair-fed controls. All alcohol-fed animals developed fatty liver. Cytotoxicity of mononuclear cells was not observed when rabbit hepatocytes were used as target cells, but mononuclear cells of alcohol-fed baboons were cytotoxic against hepatocytes of both control animals and hepatocytes from alcohol-fed baboons, including the animals' own hepatocytes. Increased vulnerability of hepatocytes of alcohol-fed baboons was also demonstrated since mononuclear cells of both controls and alcohol-fed animals were more cytotoxic against hepatocytes of alcohol-fed baboons than against those of controls. Thus, autologous and heterologous hepatocytes are more sensitive in the baboon than rabbit hepatocytes in demonstrating cytotoxicity already at the stage of fatty liver. Two factors are contributory: mononuclear cells cytotoxicity and vulnerability of hepatocytes.
在9只喂食酒精17 - 21个月的狒狒和9只配对喂食的对照狒狒中，研究了单核细胞对自体、同种异体和异种（兔）肝细胞的细胞毒性。所有喂食酒精的动物都出现了脂肪肝。当使用兔肝细胞作为靶细胞时，未观察到单核细胞的细胞毒性，但喂食酒精的狒狒的单核细胞对对照动物的肝细胞以及喂食酒精的狒狒的肝细胞（包括动物自身的肝细胞）具有细胞毒性。喂食酒精的狒狒的肝细胞易损性增加也得到了证实，因为对照动物和喂食酒精的动物的单核细胞对喂食酒精的狒狒的肝细胞的细胞毒性比对对照动物肝细胞的细胞毒性更强。因此，在脂肪肝阶段，自体和异源肝细胞在狒狒中比兔肝细胞在显示细胞毒性方面更敏感。有两个因素起作用：单核细胞的细胞毒性和肝细胞的易损性。
