Rednam K R, Jampol L M, Levine R A, Goldberg M F
Retina. 1981;1(2):100-6. doi: 10.1097/00006982-198101020-00005.
A 66-year-old man had a pigmented choroidal lesion in his right eye. Over a subsequent period of 8 1/2 years, the lesion showed slight growth. At autopsy, the diagnosis was spindle B melanoma of the choroid without evidence of systemic metastasis. A very unusual feature of this case was the presence in this patient of seven primary malignant tumors and five benign neoplasms. In addition to the choroidal melanoma, these included three distinct pulmonary carcinomas, leiomyosarcoma of the stomach, adenocarcinoma of the sigmoid colon, and basal cell carcinoma. The literature on multiple malignancies in association with uveal melanoma is reviewed.
一名66岁男性右眼有一个色素性脉络膜病变。在随后的8年半时间里，该病变有轻微生长。尸检时，诊断为脉络膜梭形B黑色素瘤，无全身转移证据。该病例的一个非常不寻常的特征是，该患者存在7个原发性恶性肿瘤和5个良性肿瘤。除脉络膜黑色素瘤外，这些肿瘤还包括3种不同的肺癌、胃平滑肌肉瘤、乙状结肠癌和基底细胞癌。本文对与葡萄膜黑色素瘤相关的多原发恶性肿瘤的文献进行了综述。
